Chromatin and cell biology
Institute of Human Genetics (IGH)
Giacomo Cavalli is a world leader in epigenetics, particularly in the analysis of epigenomes and 3D genome architecture. Giacomo’s lab masters techniques such as ChIP and RNA methodologies, Hi-C and other derivatives, confocal, live and super-resolution microscopy plus genome engineering methodologies.
The aim is to understand the principle governing 3D genome organisation, its functional implications, and the molecular mechanisms by which PcG and trxG proteins regulate their target genes, convey inheritance of chromatin states and orchestrate development.
To reach this goal, Giacomo and his team employ a variety of complementary approaches and techniques in the areas of molecular, cellular and developmental biology, genomics and bioinformatics.