Arun Kumar Sundaramurthy
PROJECT: NOVEL THERAPEUTIC TARGETS FOR THE TREATMENT OF LEUKEMIA
University of Copenhagen/ BRIC
Arun performed his master’s in Biology at the Ludwig Maximilian University of Munich. During his studies he explored different avenues of both basic and applied research by performing several short-term internships. He did his thesis project to understand the nucleosome organization of heterochromatin in Schizosaccahromyces pombe in the Müller-Planitz lab. He adopted a regulatable system to ectopically induce heterochromatin formation and mapped the nucleosome landscape by switching between hetero- and euchromatic states using an improved MNase – Seq protocol. Working on this project spurred his interest towards chromatin research. To this end, he joined the Helin lab in April 2019 and he is currently working on to identify novel epigenetic targets for the treatment of acute myeloid leukemia (AML). For this, he will utilize the Depmap datasets that provides information on the dependency of individual genes for survival in various cancer cell lines. During his PhD he will validate one or two targets in vitro and in vivo in an AML setting. Further he will explore the mechanism by which the epigenetic factor contributes to leukemia maintenance and the therapeutic potential of it will be investigated.